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While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

The combination therapy of SAHA (40 mg/kg, intraperitoneal injection every 3 days) and B7x neutralizing antibody (200 g/mouse, intraperitoneal injection every 2 days) significantly delayed tumor growth, with a tumor inhibition rate of 80.6%, and significantly increased the infiltration of CD8 + and CD4 + T cells in the tumor microenvironment (67)

Batovska et al